Construction of NIR Light Controlled Micelles with Photothermal Conversion Property: Poly(poly(ethylene glycol)methyl ether methacrylate) (PPEGMA) as Hydrophilic Block and Ketocyanine Dye as NIR Photothermal Conversion Agent
Lan Yao, Haihui Li, Kai Tu, Lifen Zhang *, Zhenping Cheng *, and Xiulin Zhu
两亲性嵌段共聚物组装而成的纳米组装体在肿瘤组织治疗方面的应用越来越广泛。在本体系中，通过RAFT聚合制备了一系列两亲性嵌段共聚物PBnMA-b-P(BAPMA-co-PEGMA)。其中BAPMA可以在三氟乙酸作用下脱BOC保护，得到PBnMA-b-P(APMA-co-PEGMA)进而与合成的两端带有羧基官能团的克酮酸菁染料NIR 800反应，对嵌段共聚物进行后修饰改性。后修饰嵌段共聚物在CH3OH/H2O共混溶剂中自组装，得到胶束。对后修饰胶束进行了光热转换性能的探究，近红外光（λmax = 810 nm, 0.028 W/cm2）照射1h后，胶束溶液温度可由20 oC升至53 oC，说明该后修饰胶束具有优秀的近红外光热转换性能。
Polymers, 2020, 12, 1181. DOI: 10.3390/polym12051181.
Construction of NIR Light Controlled Micelles with Photothermal Conversion Property: Poly(poly(ethylene glycol)methyl ether methacrylate) (PPEGMA) as Hydrophilic Block and Ketocyanine Dye as NIR Photothermal Conversion Agent
Lan Yao, Haihui Li, Kai Tu, Lifen Zhang *, Zhenping Cheng *, and Xiulin Zhu
两亲性嵌段共聚物组装而成的纳米组装体在肿瘤组织治疗方面的应用越来越广泛。在本体系中，通过RAFT聚合制备了一系列两亲性嵌段共聚物PBnMA-b-P(BAPMA-co-PEGMA)。其中BAPMA可以在三氟乙酸作用下脱BOC保护，得到PBnMA-b-P(APMA-co-PEGMA)进而与合成的两端带有羧基官能团的克酮酸菁染料NIR 800反应，对嵌段共聚物进行后修饰改性。后修饰嵌段共聚物在CH3OH/H2O共混溶剂中自组装，得到胶束。对后修饰胶束进行了光热转换性能的探究，近红外光（λmax = 810 nm, 0.028 W/cm2）照射1h后，胶束溶液温度可由20 oC升至53 oC，说明该后修饰胶束具有优秀的近红外光热转换性能。
Polymers, 2020, 12, 1181. DOI: 10.3390/polym12051181.